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Since the immunosuppressive effect of cyclosporine is dose-dependent, targeted delivery of this drug might improve efficacy by increasing the concentration of cyclosporine in the allograft.

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The resulting primary efficacy outcome was a composite of death from any cause, worsening of heart failure during the initial hospitalization (i.

Have at any time been treated with total lymphoid irradiation, monoclonal antibody, T cell vaccination, cladribine, bone marrow transplantation, azathioprine, cyclophosphamide, methotrexate, mitoxantrone, or cyclosporine.

Second-line treatments include Cyclosporine and Intravenous Immunoglobulin (IVIG).

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